The Relationships among Moral Judgement, Social Identification, and Stigmitization

Stigma has had a perceived link with the concept of morality since the Grecian era (Goffman, 1963). The purpose of this study was to see if there was a correlation between moral judgement (using the Defining Issues Test 2; DIT2), social identification (using the Identification with all Humanity Scale; IWAHS) and stigma attributions toward those with mental illness. Specifically, whether those with a heightened sense of identification with all humanity and more developed moral judgement schemas are less likely to make negative stigma attributions toward persons with mental illness. The results this study supported correlations between those variables and the attribution variables of Pity, Segregation, Anger, Help, Avoidance, Fear, and Coercion. In regression analysis, the results supported that the IWAHS could predict coercion and segregation. There was also support in those regression analyses that certain demographic variables can act as a predictor of Pity, Help, and Avoidance attributions

The Beltway and Beyond: The Struggle for Gay, Lesbian, Bisexual and Transgender Equality

I will focus primarily on the struggle in the legislative arena in Washington, DC and more importantly, in states and local communities. And I will focus on three key issues for the GLBT community: families; civil rights and the intersection with religious liberty rights; and finally, violence and hate crimes. In summary, the GLBT community is pushing ahead of these and other issues in all 50 states

Schooling for success the US federal government, the American education system and the Cold War, 1947-1957

This thesis seeks to demonstrate that, during the post war and early Cold War years, the US Federal government, and in particular the Executive branch, was inspired to increase the role which it played in the US Education system. It also seeks to chart the methods it utilised in order to do so. One inspiration was the desire to direct the US education system towards a curriculum which better benefitted the nation’s Cold War effort, including placing a greater emphasis upon scientific education and training, more tightly regulating the discussion over democratic vs. communist ideologies in the classroom and the pursuit of a greater equalisation in opportunity for African American students. Further inspiration was provided by both the widespread expansion of centralised government programs and the increased importance of education to social progress witnessed across the world after the Second World War, and both President Truman’s own personal commitment to the equalisation of education opportunity, and the Democratic Party’s pursuit of black votes during the Truman Administration. This thesis charts the Executive and Judicial branches’ innovative and unorthodox usage of the powers available to them in order to garner greater influence over the education system, and assesses the varying rates of success of these programmes in order to demonstrate the significant and irrevocable shift in the relationship between the US Federal government and the US education system which occurred during the early Cold War

Aβ Alters the DNA Methylation Status of Cell-fate Genes in an Alzheimer’s Disease Model

Alzheimer’s disease (AD) is characterized by neurofibrillary tangles and extracellular amyloid-β plaques (Aβ). Despite ongoing research, some ambiguity remains surrounding the role of Aβ in the pathogenesis of this neurodegenerative disease. While several studies have focused on the mutations associated with AD, our understanding of the epigenetic contributions to the disease remains less clear. To that end, we determined the changes in DNA methylation in differentiated human neurons with and without Aβ treatment. We isolated the DNA from neurons treated with Aβ or vehicle, and digested the two samples with either a methylation-sensitive (HpaII) or a methylation-insensitive (MspI) restriction endonuclease. The fragments were amplified and co- hybridized to a commercial promoter microarray. Data analysis revealed a subset of genomic loci that shows a significant change in DNA methylation following Aβ treatment in comparison to the control group. After mapping these loci to nearby genes, we discovered high enrichment for cell-fate genes that control apoptosis and neuronal differentiation. Finally, we incorporated three of those genes in a possible model suggesting the means by which Aβ contributes to the brain shrinkage and memory loss seen in AD

Building leaders for the UN Ocean Science Decade: A guide to supporting early career women researchers within academic marine research institutions

Diverse and inclusive marine science is now recognized as essential for addressing the complex and accelerating challenges facing marine social-ecological systems (Blythe and Cvitanovic, 2020; Lawless et al., 2021). The United Nations (UN) Decade of Ocean Science for Sustainable Development (2021–2030) identifies gender diversity as integral to achieving its objectives of “the science we need for the ocean we want” and realizing the Sustainable Development Goals. For example, SDG 5.5 specifically aims to ensure that there are equal opportunities for women’s leadership at all levels of decision-making in political, economic, and public life (UN, 2015). The importance of gender equality has also been reflected in other global initiatives, including the UN Women’s programmes on leadership and participation (UN Women, 2022)

Fostering Systems Research in Europe

No abstrac

Production of 3D printed scale models from microscope volume datasets for use in STEM education

Understanding the three-dimensional morphology of a biological sample at the microscopic level is a prerequisite to a functional understanding of cell biology, tissue development and growth. Images of microscopic samples obtained by compound light microscopy are customarily recorded and represented in two dimensions from a single orientation making it difficult to extrapolate 3D context from the 2D information. The commercialisation of fast, laser-based microscope systems (e.g. confocal, multi-photon or lightsheet microscopy) capable of generating volume datasets of microscopic samples through optical sectioning, coupled with advances in computer technology allowing accurate volume rendering of these datasets, have facilitated significant improvement in our 3D understanding of the microscopic world in virtual space. The advent of affordable 3D printing technology now offers the prospect of generating morphologically accurate, physical models from these microscope volume datasets for use in science education, outreach and engagement. 3D printed scale replicas will provide improved sensory perception, offering tactile as well as visual interaction, leading to improved understanding of structure function relationships. Here we present a technique to reliably generate detailed, physical 3D models from Z-stacks of optical sections from confocal and lightsheet microscopes using affordable, entry-level 3D printing technology. We use the technique to generate 3D printed models of a variety of different biological samples at a range of scales including pollen grains from two species of plant; blood cells from both human and earthworm species, a section of plant root; the compound eye of an ant; and a developing Zebrafish larva; all of which have been used in our teaching, engagement and outreach activities. Our methods can, in principle, be used to generate 3D printed models from microscope volume datasets of any small fluorescent or reflective samples